Zebrafish genetics gets the Scube on Hedgehog secretion.
نویسنده
چکیده
Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.
منابع مشابه
Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.
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ورودعنوان ژورنال:
- Genes & development
دوره 26 22 شماره
صفحات -
تاریخ انتشار 2012